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Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration resistant prostate cancer
Co-crystal structures of GSTO1 bound to inhibitors showed a covalent association with the active site cysteine (C32) with additional hydrophilic and hydrophobic interactions in the H-site
Add each solvent one by one: 10% DMSO 90% (20% SBE--CD in Saline) Solubility: 2.5 mg/mL (1.76 mM)
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