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To assess the effects of fibrotic agonists on IGF-1/IGF-1R expression in cardiac cells, we infused C57BL6 mice with AngII and phenylephrine (AngII/PE) through osmotic minipumps for 7 days and then isolated and plated cardiomyocytes and cardiac fibroblasts
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Subcutaneous semaglutide 1.0 mg and oral semaglutide 14 mg resulted in weight reductions of 4.5 kg and 3.7 kg, respectively, while placebo only resulted in weight reductions of 1.0 kg and 1.4 kg, respectively
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