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Optimized triagonists normalize body weight in diet-induced obese mice and enhance energy expenditure in a manner superior to that of GLP-1R mono-agonists and GLP-1R/GIPR co-agonists
As a combination , the evidence is stronger but describes CagriSema rather than cagrilintide alone
Wang W, Lu Y, Xue Z, Li C, Wang C, Zhao X, et al
Other candidates continue to advance, reflecting how active obesity drug development has become
The SUSTAIN and STEP clinical trial programmes established semaglutide as a landmark metabolic compound: STEP 1 (obesity, non-diabetic): mean body weight reduction of ~14.9% at 68 weeks (2.4mg weekly dose) SUSTAIN-6 : significant cardiovascular risk reduction in type 2 diabetes Semaglutide represented a step change in metabolic research and established the template for next-generation incretin peptides
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