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The SURMOUNT-4 trial highlighted this perfectly: participants who continued tirzepatide after an initial weight loss period continued to lose or maintain their weight, while those who switched to a placebo regained 14% of their body weight within a year

Pregnancy, breastfeeding, kidney disease, severe anemia, and neurologic symptoms may require closer follow-up

HSP70 is a negative regulator of NLRP3 inflammasome activation

Glutathione supplements or glutathione-boosting methods can help strengthen the immune system and maintain a healthy immune response

This reduction in chronic inflammatory signaling is likely responsible for the earliest subjective improvements