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Marzi M, Vigano A, Trabattoni D, Villa ML, Salvaggio A, Clerici E et al

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Tumor Suppressor p53 is Antagonized by ARC (apoptosis repressor with caspase recruitment domain) in AML

Thus, the inability to account for inhibition of IGF-2 binding to the IGF-1R is an important limitation in this study, which should be considered when assessing outcomes from human trials using IGF-1R mAbs

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