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7 GLP-1 RA Animal Studies Preclinical animal studies suggest that GLP-1 RAs have the potential to enhance autophagy, protect against mitochondrial stress, boost dopamine production, reduce neuronal loss and terminal denervation, and improve motor function

For individuals with type 2 diabetes and MASLD/MASH, treatment should preferably include glucagon-like peptide-1 (GLP-1) receptor agonist-based therapies and sodiumglucose cotransporter 2 (SGLT2) inhibitors, which have been shown to improve MASLD/MASH and provide established cardiorenal benefits

Significant reductions were observed in individuals with cardiovascular disease or at high cardiovascular risk (Class IV

Efforts to address and manage GI side effects in the use of oral semaglutide, whether through patient education, proactive symptom management, or considering alternative strategies, are essential in promoting better patient tolerance and adherence to the prescribed medication regimen