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The compound established multiple non-covalent interactions with the -tubulin binding pocket, including two carbon hydrogen bonds with LEU227 (2.40 ) and ARG275 (2.46 )
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Furthermore, studies such as the STEP-HFpEF trial with GLP-1 receptor agonists have shown optimized exercise capacity and reduced heart failure symptoms in patients
In addition, BCL2 levels were increased indicative of anti-apoptotic response in these cells after IGF-1 treatment (Fig
