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Srivastava and Ali say those findings generally align with what they see in practice

Tirzepatide: SURMOUNT trial results The SURMOUNT program represents the largest clinical trial dataset for tirzepatide weight loss

However, FAERS has well-known limitations: Reports are spontaneous and incomplete Reporting stimulated by media attention and warnings No denominator (unknown number of exposed users) Thyroid cancer not subtype-adjudicated Confirmation bias (clinicians primed to connect drug and outcome) FAERS can answer: "Is this being reported more?" It cannot answer: "Does this drug cause thyroid cancer?" Appropriate Use of FAERS: FAERS findings are hypothesis-generating signals requiring controlled observational worknot evidence of causality

But excess lipids can clog arteries, increasing the risk of heart attack and stroke

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