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Contact your GP or healthcare provider if you experience: Persistent vomiting preventing adequate fluid intake Severe abdominal pain, particularly if constant or worsening Signs of dehydration (dark urine, dizziness, reduced urination) Inability to tolerate any food or fluids for more than 24 hours Symptoms of pancreatitis (severe upper abdominal pain radiating to the back) Upper right abdominal pain, fever or yellowing of the skin/eyes (possible gallbladder problems) Changes in vision, particularly if you have diabetic retinopathy (especially with semaglutide) Patients taking insulin or sulfonylureas alongside GLP-1 medications should monitor blood glucose levels carefully, as the combination may increase the risk of hypoglycaemia
Many mass-market brands use "flow agents" like magnesium stearate or silicon dioxide to make manufacturing faster and cheaper
They are working on the 4th and 5th generations as well
AGs are often deployed on the day of patent expiry, specifically to erode the first-filer generics 180-day exclusivity advantage
Schoental R., Magee P
