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Lower levels are associated with reduced cellular energy, increased oxidative stress, and slower metabolic processes

Reciprocal regulation of TGF-beta and reactive oxygen species: a perverse cycle for fibrosis

Mood and appetite, he explained, are closely related (think of stressful eating or eating when we are sad, comfort food), and a benefit of [GLP-1 drugs] is that they help control appetite and satiety, which allows patients to make better meal choices and become healthier. So, the modest improvement in depression seen in the study may be related to weight loss, improved blood sugars, [fewer diabetes] symptoms, and likely an overall sense of patients getting healthier, Splenser hypothesized

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More commonly, they described restored movement, reduced flare frequency, improved tolerance to mechanical loading, and fewer reinjury cycles