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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
10.1093/jas/skab054.185 201
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However, when intracellular iron ions are overloaded, Fe 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Ingold et al., 2018) (Figure 4)
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