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Tumor targeting of MMP-2/9 activatable cell-penetrating imaging probes is caused by tumor-independent activation
The main types include the predominant papillary thyroid carcinoma (PTC) that accounts for 85% of the reported cases characterized by its slow growth and excellent prognosis, the follicular thyroid carcinoma (FTC) that represents approximately 1015% of the cases and is more likely to metastasize via bloodstream to other organs, the less common medullary thyroid carcinoma (MTC) which arises from parafollicular C-cells and is often linked to genetic syndromes, and the rare but aggressive anaplastic thyroid carcinoma (ATC) with poor prognosis due to rapid progression and resistance to treatments (Haddad, Elisei et al., Schmidbauer et al
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