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In-depth research into metabolic, genetic, and disease origins, along with how these factors impact drug efficacy, is essential to improve patient outcomes
However, currently the use of GLP-1 RAs is not recommended as treatment of MASLD.(3) The American Diabetes Association 2025 guidelines similarly state GLP-1 RAs are recommended in adults with diabetes, obesity, and MASLD in combination with diet and exercise for weight loss
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Third, heterogeneity in study designs, primary endpoints, and biomarker assessments limits direct comparability and generalizability
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