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In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage (Fan et al., 2020)

First marketed as Ozempic, this semaglutide has been on the market since 2017 and taken by millions of people with diabetes and obese people all over the world

Remember, visible improvements often require regular use over several weeks, so patience is key

Using a vial past its recommended storage period does not change the concentration per se, but degraded semaglutide delivers less active medication than the label concentration suggests