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Acknowledgements This work was partially supported by National Natural Science Foundation of China 81872915 (MWW), 82073904 (MWW), 81773792 (DHY), 81973373 (DHY), and 21704064 (QTZ)

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Originally engineered at Washington State University by the Harding lab and later licensed to M3 Biotechnology, Dihexa retains the angiotensin IV pharmacophore for AT4 receptor binding while incorporating N-hexanoyl and aminohexanoic acid modifications that confer metabolic stability and lipophilic BBB penetration

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