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For individuals seeking tanning or photoprotection outside of EPP, melanotan-1 represents an unregulated alternative with identical pharmacology but unverified product quality and no medical oversight
What an assessment involves A typical consultation includes: A focused history of your GLP-1 treatment (medication, dose, duration, rate of weight loss) Review of any symptoms, including subtle or partial ones Examination Review of any existing imaging Discussion of your individual risk profile, with the RELAPSTONE tool where appropriate A clear summary of the options, with no pressure to proceed If imaging is needed, this can be arranged
Nighttime administration is preferred due to the melatonin-enhancing effect
Thus, in perfect agreement with the recent ADA-EASD consensus report [6], we also encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with established ASCVD (coronary artery disease, cerebrovascular disease, or peripheral arterial disease) or multiple risk factors for ASCVD (i.e., age 55 years, obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria) whose HbA1c remains suboptimal despite initial treatment with only one of these agents