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Methods: In this prospective observational study, 45 patients with T2DM were divided into two groups according to pre-study dapagliflozin use: a dapagliflozin-nave group (Control group, n=22) and a dapagliflozin-exposed group (DAPA group, n=23)
227 MS023, another selective PRMT type I inhibitor, reduced ADMA, increased MAA and SDMA levels, and shifted PRMTs activity from type I to type II/III in cells treated with MS023
In a word, the method has the advantages of simple steps, simple and convenient operation, low synthesis cost, higher efficiency and stable product quality, greatly reduces the racemization risk of His in amino acid, and can realize industrial production