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Metabolic and neurological functions of B12 include: Energy metabolism : B12 acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes involved in cellular energy production
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These compounds work through multiple complementary mechanisms rather than single-target effects, which contributes to their broad therapeutic applications but complicates the standardized testing protocols that regulatory agencies prefer
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This highlights the critical role of microbiota-derived metabolites in immune regulation (Mager et al., 2020)
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