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The reduction of human RNR, which was suggested to follow mechanism (ii) 46 , therefore needs to be analyzed and monothiol mechanism (iii) should be also considered

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It is important to note that most of the evidence supporting the anti-tumor efficacy of GLP-1 RAs is derived from preclinical studies, including in vitro studies and animal experiments demonstrating reduced proliferation of the cancer cells, enhanced apoptosis, and modulation of oncogenic signaling pathways ( These systemic and direct molecular effects, particularly the potent anti-inflammatory actions and metabolic correction, are highly relevant to mitigating the progression of both ALD and MetALD

3 Tkalcevic VI, et al

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