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Pharmacokinetic data indicate that fasting plasma glucose (FPG) levels begin to decrease within two weeks, and steady-state plasma concentrations are typically achieved after six weeks of weekly dosing [59]
In mouse models of NASH, GLP-/GIP dual agonists have also been found to significantly reduce TG and LDL-C and increase high-density lipoprotein cholesterol (HDL-C) [127]
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