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Patients with active RA flares or uncontrolled systemic inflammation require careful monitoring if considering GLP-1 therapy alongside DMARDs
Yet perhaps the most telling development is the rise of compounding pharmacies
Sigalos et al
A FAERS-based pharmacovigilance analysis comparing tirzepatide vs semaglutide in female reports (Q1 2022Q3 2025) reported gynaecological haemorrhagic events in 0.62% of semaglutide cases (204 cases among 32,839 female-specific reports in that analysis) and did not detect a disproportionate signal vs tirzepatide
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