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In the FOURIER trial, serious infection rates were 2.3% in the evolocumab group versus 2.2% in the placebo group over a median 2.2 years, a nonsignificant difference [3]
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For individuals with pre-existing IBS, these medication-induced gastrointestinal changes could theoretically either worsen or, in rare cases, coincidentally improve certain symptoms, though this would not constitute therapeutic benefit
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