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Despite this shared mechanism, the two receptors exhibit distinct expression patterns and physiological roles that are genuinely complementary: When both axes are activated concurrently, the cAMP response in pancreatic -cells exceeds that of either agonist alone, indicating synergistic rather than merely additive intracellular signaling

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This fundamental difference in mechanism is why peptides have generated such interest despite the limitations of current evidence

GPX8 is similar to GPX7 because both have low glutathione peroxidase (GSH) activity, mainly due to the lack of domains bound to GSH