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Linagliptin-treated rats exhibited significant improvement in impaired LV diastolic function, as well as endothelial function of gastrocnemius feed arteries, and, somewhat surprisingly, this was associated with a reduction in BP [34]
Treatment of mice with DS-induced colitis (resembling human ulcerative colitis) with the human GLP-2 analog h(Gly 2 )GLP, twice daily for 10 days, reverses weight loss independent on food intake, decreases interleukin-1 expression and increased colon length, crypt depth, and mucosal area compared to treatment with saline (Drucker et al., 1999)
Pasquier, B