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Here, we report cryoelectron microscopy (cryo-EM) structures and cryo-EM 3D variability analysis of semaglutide- and taspoglutide-bound GLP-1R-Gs protein complexes

Given the substantial overlap between the neural circuits governing appetite and those involved in addictive behaviors, it is plausible that appetite-regulating peptides such as GLP-1 contribute to reduced alcohol cravings and intake, an effect that has been especially evident in individuals with obesity

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Muscle tension in the neck and throat, hypervigilance to bodily sensations, and rapid breathing patterns all contribute