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Gene expression profiling revealed distinct apoptotic pathways: low-dose exposure triggers apoptosis through cellular stress responses, while high-dose exposure primarily activates it via direct DNA damage (160)
In particular, in this subpopulation, eryptotic levels correlated with the dialysate volume
Cycle structure: 1 to 3 months on therapy, followed by 2 to 3 months off, with a 5-days-on, 2-days-off weekly schedule
This category primarily consists of ASOs, siRNAs, miRNAs, small activating RNAs (saRNAs), and the CRISPR/Cas system, which enables precise gene editing of genomic DNA
The impact of this insight was further extended by the finding that the LASSS-treated HGF (after the wash-out of un-reacted LASSS) exhibited nitration resistance to the optimal peroxynitrite-treatment (at the same 1:2000 ratio as before) as shown in Figure 2b
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