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Muscle definition emerges
Physiology of the incretin hormones, GIP and GLP-1-regulation of release and posttranslational modifications
Reactions during dose escalation are transient and typically follow the same adaptation pattern seen during initial treatment, resolving within 2 to 4 weeks at the new dose level
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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)
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