10.1038/jcbfm.2009.262 138 ShapiraM.LichtA.MilmanA.PickC
10.1176/ajp.151.10.1409 42 HietalaJ.SyvlahtiE.KuoppamkiM.HietalaJ.SyvlahtiE.HaaparantaM.et al (1995)

Practical strategies for taking zinc and iron supplements include: Take iron supplements in the morning on an empty stomach (at least 30 minutes before breakfast) with water or orange juice if desired Take zinc supplements in the evening , ideally 2-3 hours after your last meal or iron dose If gastrointestinal side effects occur with iron on an empty stomach, take it with a small amount of food, but avoid dairy products, tea, or coffee which further inhibit absorption Consider taking zinc with a light protein-containing snack to reduce potential nausea Maintain consistent timing daily to establish a routine and ensure compliance For individuals taking multivitamin preparations containing both minerals in modest amounts (typically less than 15mg of each), the competitive interaction is generally less clinically significant, and these can usually be taken together as directed on the product label

While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3
While you may be familiar with NAC for its role in immune and respiratory health, it also plays an essential role in fertility