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On July 23, 2026 Lilly reported TRIUMPH-2 (obesity with type 2 diabetes, -20.8% at 12 mg) and TRIUMPH-3 (obesity with established cardiovascular disease, -22.6% at 12 mg)
En ACHIEVE-2, orforglipron obtuvo resultados superiores en la reduccin de la HbA1c hasta un 1,7% de media, frente al 0,8% de dapagliflozina a las 40 semanas , desde una media basal de8,1%
However, the high concentration makes it harder to measure very small doses accurately
Effectiveness Comparison When it comes to semaglutide vs tirzepatide effectiveness, the clinical trial results are staggering: Semaglutide Results Average weight loss: 15-17% of body weight 83% of patients lost at least 5% of their weight 66% lost at least 10% of their weight 48% achieved 15% or greater weight loss Tirzepatide Results Average weight loss: 16-22% of body weight 91% of patients lost at least 5% of their weight 83% lost at least 10% of their weight 57% achieved 20% or greater weight loss To put this in perspective, if you weigh 200 pounds, semaglutide could help you lose 30-34 pounds on average, while tirzepatide could help you lose 32-44 pounds
Healthcare practitioners didnt have much more to help their patients than recommending lifestyle changes
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