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We estimate that people who are homozygous for the risk alleles at both the GLP1R and GIPR loci have a 14.8-fold increased odds (95% confidence interval [6.2, 35.8]) of tirzepatide-mediated vomiting, compared with those homozygous for the non-risk alleles
Interfaces 16 , 5820358216 (2024)
Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP
The physiological evidence for a direct action of GLP-1 on pancreatic acinar cells is unclear
This effect has been confirmed in several clinical trials, including the one presented below
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