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The theoretical concern is that combining compounds with overlapping or interacting biological effects particularly those influencing inflammation, metabolism, and tissue signalling could produce unpredictable outcomes

Diclofenac and omeprazole based validation of the Nrf2 model Since we are interested in the role of Nrf2 signaling in DILI, we set out to validate the constructed model as based on the general ROS-inducer DEM with two DILI inducing compounds

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10.1530/REP-17-0053 59 SansoneA.Di DatoC.de AngelisC.MenafraD.PozzaC.PivonelloR.et al (2018)