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Elder et al have described this progression and state that differences in each phase are qualitative
Consequently, modulation of the reward system represents an additional mechanism by which GLP-1 analogs may be beneficial in treating specific EDs, such as BED
A number of prospective randomised controlled trials are ongoing, to examine whether GLP-1 drugs can reduce the risk of dementia.
73 A earlier meta-analysis of data from 17 randomized placebo-controlled trials with a total of 284 participants found melatonin supplementation improved sleep parameters, but the effects were small: in a subset of 15 trials in individuals who were either healthy or had insomnia but were otherwise healthy, the time needed to fall asleep decreased by 3.9 minutes, sleep efficiency improved by 3.1%, and total sleep time increased 13.7 minutes
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