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The proposed mechanism: the leucine substitution increases hydrophobicity, potentially stabilizing the signal peptide and improving receptor trafficking to the cell surface meaning more receptor, more drug response

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Brzozowski, A

HBPs typically have semblable chemical and structural properties to dendritic macromolecules, but are easier to synthesize and can achieve high drug loads through covalent coupling

(3) characteristics of the exercise protocol (duration in weeks, number of weekly sessions, duration of each exercise session, description of exercise)