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Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)
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Those numbers are part of why retatrutide has drawn so much attention
In addition, first-party data is becoming more valuable
Particularly because insulin often causes weight gain, healthcare providers prescribe metformin off-label (not for intended use approved by regulatory agencies) to their patients
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