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This is noteworthy as these analogues are at least 10-fold less potent then GLP-1-G 2 ( 1 ), meaning that even if at least 10 times more compound is required to get the same activity in vitro, they have a significant longer acting period

Hurtado-Carneiro V, Sanz C, Roncero I, Vazquez P, Blazquez E, Alvarez E

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Semaglutide is metabolized through protein degradation rather than hepatic metabolism, but alcohol can worsen liver disease and impair the liver's ability to regulate blood glucose