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Purging (from retinol or AHAs) occurs in acne-prone areas, peaks at 24 weeks, and typically resolves by 68 weeks

Before starting treatment, provide a full list of all medicines you take, including prescriptions, pharmacy products, and supplements

Community protocols hold each step at least 4 weeks and step back if a compound can't be tolerated

2 John Peel encourages patience with the process: The hardest part about following through with any program, especially when it's built around strength, is trusting the process

CMS also says more details would be released in early 2026so specifics could change as formal guidance is published