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4-Hydroxyproline is abundant in mammalian milk and plasma (mM range) in the peptide form [primarily glycyl-prolyl-4-hydroxyproline (Gly-Pro-Hyp)], and free 4-hydroxyproline is also present in these physiological fluids (M range)
10.1001/jama.276.12.955
Patients with certain rare medical conditions should discuss with their provider first
If the individual has significant accumulation (older age, chronic disease, prior chemotherapy), the first course may produce the most noticeable effects Subsequent courses: Target newly accumulated senescent cells
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