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Expected Weight Loss: In the head-to-head SURMOUNT-5 trial published in The New England Journal of Medicine , tirzepatide was shown to be superior to semaglutide for reduction in body weight and waist circumference at 72 weeks among adults with obesity (without diabetes)
Phototype and natural pigment distribution In phototypes IV to VI, melanin distribution across the lip surface is naturally uneven
2.5 Anti-angiogenic effect Abnormal angiogenesis plays a significant role in the pathogenesis of several eye diseases, particularly those involving retinal ischemia and neovascularization
Sci., 61, 4958, 2023
The following features would enhance the value of an obesity therapeutic, but would likely be assessed in follow-up trials or even post-approval: Additional efficacy in obesity-related co-morbidities
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