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Despite the fact that the dimeric macrocycles tightly bind to the ectodomain of human Met and induce various cellular responses in human cells, they did not show any binding activity to that of murine or canine Met (Supplementary Table 3 and Supplementary Fig

These investigations help researchers understand interactions between metabolic enzymes and cellular regulatory systems

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Method for preparing DMSO master liquid: mg drug pre-dissolved in L DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug