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That is the conclusion of a draft report (PDF) from the influential Institute for Clinical and Economic Review (ICER), a US healthcare technology assessment (HTA) organisation, which notes that access to the GLP-1 drugs is already limited by "variable insurance coverage and high out-of-pocket costs." ICER concludes in its document that Novo Nordisk's Wegovy (semaglutide) and Lilly's Zepbound (tirzepatide) are clearly a step forward in helping people lose weight and improve their metabolic health, after saying in an earlier report (PDF) that their prices needed to come down
Treatment with oral semaglutide results in slightly less weight loss compared with injectable semaglutide, with uncertainty regarding the degree of cardiovascular benefit
Since 90% of the bodys serotonin originates in the gut, these peripheral effects could influence central serotonergic tone through vagal signaling
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