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Tacrolimus: In a pediatric patient with idiopathic nephrotic syndrome, clinically relevant increases in tacrolimus concentrations and renal toxicity occurred when berberine was added to control diarrhea (30)

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We began the epic journey of MK-0616 a decade ago, and in the years since thousands of people in teams across the world have worked together, tirelessly and with joy, to steadily progress this beautiful molecule from a crazy idea that shouldn't have worked to an FDA-approved medicine that has the potential to improve the lives of millions of people