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Consequently, this comprehensive review sought (i) to investigate the existing research regarding the effects of GLP-1Ra on bone metabolism, encompassing both preclinical studies and human trials and (ii) the current knowledge related to the impact on bone metabolism of weight loss following calorie restriction and metabolic/bariatric surgery

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Current insight into the cardiovascular biology of GIP is limited, and findings in preclinical and clinical studies point in different directions, ranging from potentially cardioprotective effects to heightened vascular inflammation and artherogenesis 24,25

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