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Normally, a liver enzyme called FMO3 performs this conversion

Variants in GIPR (the GIP receptor relevant to tirzepatide), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

Protein, fibre, and other nutrients like potassium, calcium, sodium, and particular vitamins also align with eating less, but not quite as much

It changes whether the peptide reaches those tissues in the first place