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Cagrilintide Phase 2 monotherapy (Lau et al., Lancet 2021) reported about 10.8% weight loss at 26 weeks at 4.5 mg

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al

If you must take it during the day, make sure you have not eaten 2 hours beforehand

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

While retatrutide Phase 2 data showed improvements in cardiovascular risk markers, individual responses vary, and new cardiac symptoms during any peptide protocol should be evaluated immediately