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Neurological Manifestation Treatment Doses For those with B12 deficiency symptoms like nerve problems or brain fog, treatment needs to be stronger
There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH
Both alcohol use and alcohol related deaths increased in the US during the COVID-19 pandemic 5,6
Performance & recovery: Glutathione injection, then on noninjection days use NAC and glycine (a GlyNAC style approach) to support endogenous glutathione
DOI: 10.1056/NEJMoa0909747
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