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Consistent with the results in the CM animal model, GLP-1R is completely colocalized with BV-2 microglia, and activation of GLP-1R by liraglutide reduced Iba-1 protein expression and inflammatory factors
The two molecules sit in the same melanocortin neighbourhood, but their receptor profiles, evidence bases, regulatory histories, and sourcing cautions are materially different
Issued January 6, 2015
A significant reduction in PEth levels was observed at week 26 in the exenatide group compared to placebo, though no differences emerged earlier
The ceiling dose is 1.0mg daily exceeding this provides no proportional increase in melanogenesis but significantly increases off-target melanocortin receptor activation
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