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GSH levels in macrophages, directly affect the Th1/Th2 cytokine response, and more specifically, GSH depletion inhibits Th1-associated cytokine production and/or promotes Th2 associated responses (Fraternale et al., 2006)

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[6] [9] Exendin-4, however, remains active in the bloodstream for several hours, making it a more practical therapeutic option