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In the context of tumor immune microenvironment remodeling, the SSP induces an immunosuppressive phenotype, promotes M2-type macrophage polarization, sustains high PD-L1 expression, impairs the cytotoxic function of CD8 + T cells, and compromises the therapeutic efficacy of CAR-T cells

2020 Feb;9(1):10-13

The brain and nervous system are particularly susceptible to oxidative stress, in part because of the high percentage of oxygen required for healthy brain function

They suggested that SSRIs are associated with an increased risk of fetal congenital malformations, although this risk is small and does not support the possibility of a significant teratogenic effect of SSRIs

Front Psychiatry 8:278204