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Thus, several studies have demonstrated the presence of prohormone convertase 1/3 [PC1/3, the processing enzyme that cleaves proglucagon to generate GLP-1 (105)] and fully processed GLP-1 in rodent and human -cells and islets in culture (106110), and GLP-1 can be detected in the media, suggesting that it is secreted from the -cells

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therefore, this exposure was retained for descriptive completeness but was not used to support inferences regarding relative switching stability