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Studies have shown that PLD can exert therapeutic effects on DR in vivo by downregulating the ferroptosis-related TLR4/MyD88/NF-B p65 pathway and upregulating the Nrf2/HO-1 pathway (226)
Future studies should focus on the metatranscriptome of the gut to better assess the microbial contribution to GR conversion
However, there are no controlled human clinical trials for TB-500, and clinical research for thymosin beta-4 is limited and indication-specific
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